Galaxy morphology and star formation in the Illustris Simulation at z = 0

We study how optical galaxy morphology depends on mass and star formation rate (SFR) in the Illustris Simulation. To do so, we measure automated galaxy structures in 10808 simulated galaxies at z=0 with stellar masses 10^9.7 < M_*/M_sun < 10^12.3. We add observational realism to idealized synthetic images and measure non-parametric statistics in rest-frame optical and near-IR images from four directions. We find that Illustris creates a morphologically diverse galaxy population, occupying the observed bulge strength locus and reproducing median morphology trends versus stellar mass, SFR, and compactness. Morphology correlates realistically with rotation, following classification schemes put forth by kinematic surveys. Type fractions as a function of environment agree roughly with data. These results imply that connections among mass, star formation, and galaxy structure arise naturally from models matching global star formation and halo occupation functions when simulated with accurate methods. This raises a question of how to construct experiments on galaxy surveys to better distinguish between models. We predict that at fixed halo mass near 10^12 M_sun, disc-dominated galaxies have higher stellar mass than bulge-dominated ones, a possible consequence of the Illustris feedback model. While Illustris galaxies at M_* ~ 10^11 M_sun have a reasonable size distribution, those at M_* ~ 10^10 M_sun have half-light radii larger than observed by a factor of two. Furthermore, at M_* ~ 10^10.5-10^11 M_sun, a relevant fraction of Illustris galaxies have distinct "ring-like" features, such that the bright pixels have an unusually wide spatial extent

Fault-Tolerant Hotelling Games

The $n$-player Hotelling game calls for each player to choose a point on the line segment, so as to maximize the size of his Voronoi cell. This paper studies fault-tolerant versions of the Hotelling game. Two fault models are studied: line faults and player faults. The first model assumes that the environment is prone to failure: with some probability, a disconnection occurs at a random point on the line, splitting it into two separate segments and modifying each player's Voronoi cell accordingly. A complete characterization of the Nash equilibria of this variant is provided for every $n$. Additionally, a one to one correspondence is shown between equilibria of this variant and of the Hotelling game with no faults. The second fault model assumes the players are prone to failure: each player is removed from the game with i.i.d. probability, changing the payoffs of the remaining players accordingly. It is shown that for $n \geq 3$ this variant of the game has no Nash equilibria

Oral rehydration versus intravenous therapy for treating dehydration due to gastroenteritis in children: a meta-analysis of randomised controlled trials

BACKGROUND: Despite treatment recommendations from various organizations, oral rehydration therapy (ORT) continues to be underused, particularly by physicians in high-income countries. We conducted a systematic review of randomised controlled trials (RCTs) to compare ORT and intravenous therapy (IVT) for the treatment of dehydration secondary to acute gastroenteritis in children. METHODS: RCTs were identified through MEDLINE, EMBASE, CENTRAL, authors and references of included trials, pharmaceutical companies, and relevant organizations. Screening and inclusion were performed independently by two reviewers in order to identify randomised or quasi-randomised controlled trials comparing ORT and IVT in children with acute diarrhea and dehydration. Two reviewers independently assessed study quality using the Jadad scale and allocation concealment. Data were extracted by one reviewer and checked by a second. The primary outcome measure was failure of rehydration. We analyzed data using standard meta-analytic techniques. RESULTS: The quality of the 14 included trials ranged from 0 to 3 (Jadad score); allocation concealment was unclear in all but one study. Using a random effects model, there was no significant difference in treatment failures (risk difference [RD] 3%; 95% confidence intervals [CI]: 0, 6). The Mantel-Haenzsel fixed effects model gave a significant difference between treatment groups (RD 4%; 95% CI: 2, 5) favoring IVT. Based on the four studies that reported deaths, there were six in the IVT groups and two in ORT. There were no significant differences in total fluid intake at six and 24 hours, weight gain, duration of diarrhea, or hypo/hypernatremia. Length of stay was significantly shorter for the ORT group (weighted mean difference [WMD] -1.2 days; 95% CI: -2.4,-0.02). Phlebitis occurred significantly more often with IVT (number needed to treat [NNT] 33; 95% CI: 25,100); paralytic ileus occurred more often with ORT (NNT 33; 95% CI: 20,100). These results may not be generalizable to children with persistent vomiting. CONCLUSION: There were no clinically important differences between ORT and IVT in terms of efficacy and safety. For every 25 children (95% CI: 20, 50) treated with ORT, one would fail and require IVT. The results support existing practice guidelines recommending ORT as the first course of treatment in appropriate children with dehydration secondary to gastroenteritis

Random-key cuckoo search for the travelling salesman problem

Combinatorial optimization problems are typically NP-hard, and thus very challenging to solve. In this paper, we present the random key cuckoo search (RKCS) algorithm for solving the famous Travelling Salesman Problem (TSP). We used a simplified random-key encoding scheme to pass from a continuous space (real numbers) to a combinatorial space. We also consider the displacement of a solution in both spaces using L\'evy flights. The performance of the proposed RKCS is tested against a set of benchmarks of symmetric TSP from the well-known TSPLIB library. The results of the tests show that RKCS is superior to some other metaheuristic algorithms

Analogue peptides for the immunotherapy of human acute myeloid leukemia

Accepted manuscript. The final publication is available at: http://link.springer.com/article/10.1007%2Fs00262-015-1762-9The use of peptide vaccines, enhanced by adjuvants, has shown some efficacy in clinical trials. However, responses are often short-lived and rarely induce notable memory responses. The reason is that self-antigens have already been presented to the immune system as the tumor develops, leading to tolerance or some degree of host tumor cell destruction. To try to break tolerance against self-antigens, one of the methods employed has been to modify peptides at the anchor residues to enhance their ability to bind major histocompatibility complex molecules, extending their exposure to the T-cell receptor. These modified or analogue peptides have been investigated as stimulators of the immune system in patients with different cancers with variable but sometimes notable success. In this review we describe the background and recent developments in the use of analogue peptides for the immunotherapy of acute myeloid leukemia describing knowledge useful for the application of analogue peptide treatments for other malignancies

The merger rate of galaxies in the Illustris simulation: A comparison with observations and semi-empirical models

We have constructed merger trees for galaxies in the Illustris simulation by directly tracking the baryonic content of subhaloes. These merger trees are used to calculate the galaxy-galaxy merger rate as a function of descendant stellar mass, progenitor stellar mass ratio, and redshift. We demonstrate that the most appropriate definition for the mass ratio of a galaxy-galaxy merger consists in taking both progenitor masses at the time when the secondary progenitor reaches its maximum stellar mass. Additionally, we avoid effects from 'orphaned' galaxies by allowing some objects to 'skip' a snapshot when finding a descendant, and by only considering mergers which show a well-defined 'infall' moment. Adopting these definitions, we obtain well-converged predictions for the galaxy-galaxy merger rate with the following main features, which are qualitatively similar to the halo-halo merger rate except for the last one: a strong correlation with redshift that evolves as ~(1 + z)2.4-2.8, a power law with respect to mass ratio, and an increasing dependence on descendant stellar mass, which steepens significantly for descendant stellar masses greater than ~2 × 1011M⊙. These trends are consistent with observational constraints for medium-sized galaxies (M* ≳ 1010M⊙), but in tension with some recent observations of the close pair fraction for massive galaxies (M* ≳ 1011M⊙), which report a nearly constant or decreasing evolution with redshift. Finally, we provide a fitting function for the galaxy-galaxy merger rate which is accurate over a wide range of stellar masses, progenitor mass ratios, and redshifts

Toward High‐Thermoelectric‐Performance Large‐Size Nanostructured BiSbTe Alloys via Optimization of Sintering‐Temperature Distribution

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/133629/1/aenm201600595-sup-0001-S1.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133629/2/aenm201600595_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/133629/3/aenm201600595.pd

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

BACKGROUND: The liver is the central organ for xenobiotic metabolism (XM) and is regulated by nuclear receptors such as CAR and PXR, which control the metabolism of drugs. Here we report that gut microbiota influences liver gene expression and alters xenobiotic metabolism in animals exposed to barbiturates. PRINCIPAL FINDINGS: By comparing hepatic gene expression on microarrays from germfree (GF) and conventionally-raised mice (SPF), we identified a cluster of 112 differentially expressed target genes predominantly connected to xenobiotic metabolism and pathways inhibiting RXR function. These findings were functionally validated by exposing GF and SPF mice to pentobarbital which confirmed that xenobiotic metabolism in GF mice is significantly more efficient (shorter time of anesthesia) when compared to the SPF group. CONCLUSION: Our data demonstrate that gut microbiota modulates hepatic gene expression and function by altering its xenobiotic response to drugs without direct contact with the liver

Marine Biodiversity in South Africa: An Evaluation of Current States of Knowledge

Continental South Africa has a coastline of some 3,650 km and an Exclusive Economic Zone (EEZ) of just over 1 million km2. Waters in the EEZ extend to a depth of 5,700 m, with more than 65% deeper than 2,000 m. Despite its status as a developing nation, South Africa has a relatively strong history of marine taxonomic research and maintains comprehensive and well-curated museum collections totaling over 291,000 records. Over 3 million locality records from more than 23,000 species have been lodged in the regional AfrOBIS (African Ocean Biogeographic Information System) data center (which stores data from a wider African region). A large number of regional guides to the marine fauna and flora are also available and are listed

Raising the profile of pilot and feasibility studies in relation to the development, evaluation and implementation of patient-reported outcome measures.

This editorial introduces a new special series on the pilot and feasibility testing of patient-reported outcome measures (PROMs) in the on-line open access journal Pilot and Feasibility Studies. Pilot and feasibility studies are typically implemented to address issues of uncertainty before undertaking a larger definitive study such as a randomised controlled trial or large scale survey. This editorial considers the role that such pilot and feasibility testing plays in relation to the development, evaluation and implementation of PROMs. This is often an essential element of PROM research but is typically overlooked-especially within current methodological guidance, reporting space and also debate. This editorial aims to open up a dialogue about the role of pilot and feasibility testing in relation to PROMs. It highlights some of the areas in PROMs research where these types of studies have been carried out and discusses the ways in which the PROM community may be better supported and encouraged to integrate this element of the research process into their PROM-based work